Catechol-O-methyltransferase: potential relationship to idiopathic hypertension
نویسندگان
چکیده
منابع مشابه
Catechol-O-methyltransferase: potential relationship to idiopathic hypertension
Catecholamine signaling pathways in the peripheral and central nervous systems (PNS, CNS, respectively) utilize catechol-O-methyltransferase (COMT) as a major regulatory enzyme responsible for deactivation of dopamine (DA), norepinephrine (NE) and epinephrine (E). Accordingly, homeostasis of COMT gene expression is hypothesized to be functionally linked to regulation of autonomic control of nor...
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The introduction of levodopa therapy for Parkinson’s disease (PD), initially by Birkmayer and colleagues in 1961 and Barbeau and colleagues in 1962, and in its ultimately successful form by Cotzias and colleagues in 1967, still represents the defining landmark in the treatment of PD (1–3). This dramatic advance was preceded by methodical basic laboratory research in the late 1950s and early 196...
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Parkinson's disease (PD) is one of the main causes of neurological disability in the elderly. Levodopa is the gold standard for treating this disease, but chronic levodopa therapy is complicated by motor fluctuation and dyskinesia. The catechol-O-methyltransferase (COMT) inhibitors represent a new class of antiparkinsonian drugs. When coadministered with levodopa/decarboxylase inhibitor, 2 COMT...
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BACKGROUND Cognitive dysfunction in the working memory domain seems to be under genetic control and is a candidate intermediate phenotype in schizophrenia. Genes that affect working memory processing may contribute to risk for schizophrenia. METHODS Working memory and attentional processing were assessed in a large and unselected sample of schizophrenic patients, their healthy siblings, and c...
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ژورنال
عنوان ژورنال: Archives of Medical Science
سال: 2010
ISSN: 1734-1922
DOI: 10.5114/aoms.2010.14246